Seek a balance between having too many projects where they slow each other's progress, and too few where a company risks its ability to survive with only a few projects that may or may not succeed and achieve the company's goals. A balance does not mean equal numbers.

Seek a balance between initiating too many high risk projects where you make assumptions of how a drug will behave, and being too conservative and avoiding most risks, by not wanting to make assumptions of how a drug will act.

The state-of-the-art is becoming so advanced in several technical areas that it is not the most appropriate standard to use for medical product development. For example, minute amounts of a drug may be measured in blood, but those levels are not needed or used to make clinical decisions and do not provide relevant safety data.