Truly great scientists do not generally make good managers. Creative scientists must be encouraged, stimulated and rewarded so that they are happy to remain creative scientists.

Good managers do not generally make good leaders. Good leaders will have charisma, charm and qualities that encourage people to follow them. Good managers have other traits that get things done efficiently and on-time and on-budget.

The regulatory cascade consists of laws that lead to regulations, which lead to guidelines, which lead to points to consider, which lead to formal recommendations, which lead to podium policy, which lead to informal comments, and which finally lead to gossip.

Harmonizing regulations at ICH prospectively before any regulations exist is a lot easier and more efficient than attempting to harmonize them retrospectively, where three different sets of regulations exist and have to be harmonized into a single whole.

When you are asked for a date when you can complete an assignment, always ask: "When is it needed?"